4-[(2,4-二氯-5-甲氧基苯基)氨基]-7-氟-6-甲氧基-3-喹啉甲腈合成路线 （共 5 条）
反应条件
1: 4-(3-hydroxypropyl)-1-methylpiperazine With sodium hydride in N,N-dimethyl-formamide T=100°C; 0.0833333 h; 2: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile in N,N-dimethyl-formamide T=120°C; 2 h;
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
pyridine hydrochloride in 2-ethoxy-ethanol
T=120°C; 3 h;
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
trichlorophosphate in methanol; acetonitrile
26 h; Heating;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1: 42 percent / toluene / 4.5 h / 100 - 110 °C
2: 77 percent / POCl3 / 0.5 h / Heating
3: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C
View Scheme
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
1: 77 percent / POCl3 / 0.5 h / Heating
2: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C
View Scheme
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
