4-氯-7-氟-6-(苯基甲氧基)-3-喹啉甲腈合成路线 (共 2 条)
反应条件
1: With trichlorophosphate
T=115°C; 1.5 h;
2: With ammonia in water
T=0°C;
参考文献
Wyeth Holdings Corporation
Patent: US2003/212276 A1, 2003 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With methyl-phenyl-thioether; trifluoroacetic acid
9 h; Heating / reflux;
2: With ammonia in water
pH=9 - 10;
参考文献
Wyeth Holdings Corporation
Patent: US2003/212276 A1, 2003 ;
Location in patent: Page/Page column 12-13 ;