4-氯-7-氟-6-羟基-3-喹啉甲腈合成路线 （共 2 条）
反应条件
1: With methyl-phenyl-thioether; trifluoroacetic acid
9 h; Heating / reflux;
2: With ammonia in water
pH=9 - 10;
参考文献
WYETH
Patent: WO2005/47259 A1, 2005 ;
Location in patent: Page/Page column 11; 24-25 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0 - 20°C;
参考文献
Wyeth Holdings Corporation
Patent: US2003/212276 A1, 2003 ;
Location in patent: Page/Page column 13 ;
