1-(1-三苯甲基-4-)乙醇合成路线 (共 4 条)
反应条件
manganese(IV) oxide in 1,4-dioxane T=0°C; 2 h; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4096 A1, 2008 ;
Location in patent: Page/Page column 79-80 ;
反应条件
in tetrahydrofuran; diethyl ether
Grignard reaction; 1 h;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
methyl-magnesium iodide; ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Institut National de la Sante et de la Recherche Medicale (INSERM); Bioproject
Patent: US5034539 A1, 1991 ;
US 5034539 A
反应条件
ethylmagnesium bromide
1) Et2O, CH2Cl2, 30 min, r.t. 2) 16 h; Yield given. Multistep reaction;
参考文献
Turner, Richard M.; Lindell, Stephen D.; Ley, Steven V.
Journal of Organic Chemistry, 1991 , vol. 56, # 20 p. 5739 - 5740