2,2,2-三氟乙基三氟甲烷磺酸酯合成路线 （共 31 条）
参考文献
FR1470669 , ;
C.A., , vol. 67, p. 63788
反应条件
20°C for 48 h, after 110°C for 2.5 h;
参考文献
Tetrahedron, , vol. 21, p. 1 - 4
反应条件
potassium carbonate in acetone T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/822 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/000822 A1
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/21500 A1, 2011 ;
Location in patent: Page/Page column 42 ;
反应条件
caesium carbonate in acetonitrile T=85°C; 3 h; Inert atmosphere;
参考文献
Yang, Qingliang; Njardarson, Jon T.
Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7080 - 7082
反应条件
cesium fluoride in diethylene glycol dimethyl ether T=20°C; 24 h; Product distribution; Further Variations:ReagentsTemperaturesSolventstime;
参考文献
Murata, Junji; Tamura, Masanori; Sekiya, Akira
Journal of Fluorine Chemistry, 2002 , vol. 113, # 1 p. 97 - 100
反应条件
1: 6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.5 h; 2: trifluoromethylsulfonyloxy-2,2,2-trifluoroethane in N,N-dimethyl-formamide; mineral oil T=20°C;
参考文献
MERCK and CO., INC.
Patent: WO2008/156580 A1, 2008 ;
Location in patent: Page/Page column 43-44 ;
WO 2008/156580 A1
反应条件
in xylene 48 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/21500 A1, 2011 ;
Location in patent: Page/Page column 40-41 ;
反应条件
potassium hydrogencarbonate in acetone
参考文献
Riker Laboratories, Inc.
Patent: US3996280 A1, 1976 ;
反应条件
in toluene T=100°C; 48 h;
参考文献
Hanamoto, Takeshi; Morita, Noriko; Shindo, Keiko
European Journal of Organic Chemistry, 2003 , # 21 p. 4279 - 4285
