2,2,2-三氟乙基三氟甲烷磺酸酯合成路线 （共 31 条）
反应条件
potassium tert-butylate in tetrahydrofuran 48 h; Heating;
参考文献
Tetrahedron, , vol. 44, # 17 p. 5375 - 5387
反应条件
18-crown-6 ether; potassium carbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=60°C; 24 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
sodium hydrogencarbonate in ethanol
T=80°C; 6 h;
参考文献
sanofi-aventis
Patent: US2008/269170 A1, 2008 ;
Location in patent: Page/Page column 52 ;
反应条件
potassium carbonate in acetone
T=20°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/822 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/000822 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.
Patent: WO2014/8214 A1, 2014 ;
Location in patent: Paragraph 00500-00501 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
1: 2-hydroxy-5-bromo-benzoic aldehyde With sodium hydride in N,N-dimethyl-formamide
T=10 - 35°C; 0.5 h;
2: trifluoromethylsulfonyloxy-2,2,2-trifluoroethane in N,N-dimethyl-formamide
T=65°C; 2 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 95 ;
WO 2007/015588 A1
反应条件
potassium carbonate in acetonitrile
T=20°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 75 ;
WO 2004/041829 A1
参考文献
Tsushima; Kawada; Ishihara; Uchida; Shiratori; Higaki; Hirata
Tetrahedron, 1988 , vol. 44, # 17 p. 5375 - 5387
反应条件
potassium hydrogencarbonate in water; acetone
参考文献
Riker Laboratories, Inc.
Patent: US3996280 A1, 1976 ;
