2,2’-[亚甲基双(氧亚甲基)]双[2-羟甲基]-1,3-丙二醇合成路线 （共 9 条）
反应条件
oxalic acid; di(n-butyl)tin oxide in toluene
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US4883902 A1, 1989 ;
反应条件
nitric acid Yield given;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
反应条件
hydrogenchloride T=80°C; 2 h; Title compound not separated from byproducts;
参考文献
Liebigs Annalen der Chemie, , # 6 p. 938 - 945
反应条件
Heatingheating more than 149 deg C;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
反应条件
ion exchanger Lewatit MP 5 (OH-form) in methanol
T=50°C; 1 h; yield: 70-80 percent;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
反应条件
methyllithium
Title compound not separated from byproducts;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
反应条件
in water
T=10°C; and equilibrium constants; Rate constantMechanismProduct distribution;
参考文献
Belkin, D. I.
J. Appl. Chem. USSR (Engl. Transl.), 1990 , vol. 63, # 10 p. 2312 - 2320,2132 - 2139
反应条件
hydrogenchloride
T=80°C; 2 h; Title compound not separated from byproducts;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
反应条件
Heatingheating more than 149 deg C;
参考文献
Werle, Peter; Nonnenmacher, Gerhard; Kruse, Karsten
Liebigs Annalen der Chemie, 1980 , # 6 p. 938 - 945
