[3-甲基-5-(2,6,6-三甲基-1-环己烯-1-基)-2,4-戊二烯基]三苯基溴化鏻合成路线 （共 14 条）
反应条件
1: With sodium hydroxide in isopropyl alcohol T=20 - 30°C; Wittig Olefination; 3 h; Inert atmosphere; 2: With hydrogenchloride; palladium diacetate in isopropyl alcohol T=60°C; pH=7 - 8;
参考文献
Chongqing Huabangshengkai Pharm. Co., Ltd; DENG, Qingjun; WANG, Shaohui; ZHU, Qiang; GAO, Taiping; LI, Yongsheng
Patent: EP2708530 A1, 2014 ;
Location in patent: Paragraph 0043; 0044 ;
反应条件
1: With 18-crown-6 ether; potassium tert-butylate in dichloromethane T=-78 - 20°C; 12 h; 2: With lithium aluminium tetrahydride in diethyl ether T=0°C; 0.5 h; Product distribution / selectivity;
参考文献
US2008/249042 A1, ;
Page/Page column 2; 19; 22; Sheet 22/24 ;
反应条件
tetrabutyl ammonium fluoride 1.) Wittig-reaction; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 110, # 17 p. 5915 - 5917
反应条件
1: (2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate With lithium aluminium tetrahydride in diethyl ether
T=0°C; 0.5 h;
2: triphenylphosphine hydrobromide in methanol
T=20°C; 24 h;
参考文献
UNIVERSITY OF WASHINGTON
Patent: US2008/249042 A1, 2008 ;
Location in patent: Page/Page column 2; 19; 22; Sheet 22/24 ;
反应条件
in methanol
75 h; Ambient temperature;
参考文献
Curley Jr.; DeLuca
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 1941 - 1944
反应条件
in methanol; dichloromethane; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US4544770 A1, 1985 ;
反应条件
1: 100 percent / tetrahydrofuran / 20 h / 20 °C
2: 73 percent / methanol / 20 h / 20 °C
View Scheme
参考文献
Haugan, Jarle Andre
Acta Chemica Scandinavica, 1994 , vol. 48, # 8 p. 657 - 664
反应条件
1: LiAlH4 / diethyl ether / 0.25 h / Ambient temperature
2: methanol / 17 h / Ambient temperature
View Scheme
参考文献
Ito, Masayoshi; Katsuta, Yuko; Yamano, Yumiko; Tsukida, Kiyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 8 p. 987 - 994
反应条件
1: Acetic acid (2Z,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl ester With lithium aluminium tetrahydride
2: triphenylphosphine hydrobromide
参考文献
Hirano, Takahiro; Lim, In Taek; Kim, Don Moon; Zheng, Xiang-Guo; Yoshihara, Kazuo; Oyama, Yoshiaki; Imai, Hiroo; Shichida, Yoshinori; Ishiguro, Masaji
Photochemistry and Photobiology, 2002 , vol. 76, # 6 p. 606 - 615
反应条件
in methanol
17 h; Ambient temperature;
参考文献
Ito, Masayoshi; Katsuta, Yuko; Yamano, Yumiko; Tsukida, Kiyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 8 p. 987 - 994
