1: para-bromobenzonitrile With magnesium in tetrahydrofuran
T=-78°C; Metallation; 0.25 h;
2: 3-iodoprop-1-ene With copper(l) iodide in tetrahydrofuran
T=-78 - -40°C; Substitution; 2 h; Further stages.;
参考文献
Lee, Jun-Sik; Velarde-Ortiz, Raffet; Guijarro, Albert; Wurst, Joshua R.; Rieke, Reuben D.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5428 - 5430