反应条件
1.1: 1-methyl-piperazine / toluene / Heating 1.2: 5 h / Reflux 2.1: 5 Pd(II)/C(eggshell); hydrogen / 1,1-dimethylpropan-1-ol / 80 °C / 5171.62 Torr 3.1: 1,1-dimethylpropan-1-ol / 70 °C / Resolution of racemate; Large scale reaction 4.1: potassium carbonate / water; toluene / 6 h / 50 °C View Scheme
参考文献
Dirat, Olivier; Bibb, Andrew J.; Burns, Colin M.; Checksfield, Graham D.; Dillon, Barry R.; Field, Stuart E.; Fussell, Steven J.; Green, Stuart P.; Mason, Clive; Mathew, Jinu; Mathew, Suju; Moses, Ian B.; Nikiforov, Petar I.; Pettman, Alan J.; Susanne, Flavien
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1010 - 1017