1,4-二(溴甲基)苯 合成路线 （共 136 条）
反应条件
1: 18-crown-6 / acetonitrile / 16 h / Ambient temperature
2: 1) Zn, BrCH2CH2Br, 3) CuCN, LiCl / 1) THF, 5 deg C, 3 h, 2) THF, -75 to -20 deg C, 3) THF, -70 deg C to RT, 14 h
3: 96 percent / K2CO3, MeOH / 1 h / Ambient temperature
4: 80 percent / pyridine / CH2Cl2 / 3 h / 0 °C
View Scheme
参考文献
Isaacs, Lyle; Haldimann, Richard F.; Diederich, Francois
反应条件
1: 3 h / 80 - 90 °C
2: KI, aq. benzyltrimethylammonium hydroxide / dioxane / 6 h / Ambient temperature
3: 60 percent / 1 N aq. HCl / diethyl ether / 2 h / Ambient temperature
4: 43 percent / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight
5: 40 percent
6: 84 percent / 6 N aq. HCl / 4 h / Heating
View Scheme
参考文献
Garbay-Jaureguiberry; McCort-Tranchepain; Barbe; Ficheux; Roques
参考文献
Baciocchi, Enrico; Mattioli, Mario; Romano, Roberta; Ruzziconi, Renzo
→
反应条件
283-80-7 四环[14.2.2.24,7.210,13]二十四碳-4,6,10,12,16,18,19,21,23-九烯
反应条件
sodium; tetraphenylethylene in tetrahydrofuran; toluene
Heating;
参考文献
Rathore, Rajendra; Chebny, Vincent J.; Abdelwahed, Samen H.
→
反应条件
283-80-7 四环[14.2.2.24,7.210,13]二十四碳-4,6,10,12,16,18,19,21,23-九烯 +
反应条件
sodium; tetraphenylethylene in tetrahydrofuran
96 h; Heating;
参考文献
Schmidbaur, Hubert; Hager, Rudolf; Huber, Brigitte; Mueller, Gerhard
→
反应条件
283-80-7 四环[14.2.2.24,7.210,13]二十四碳-4,6,10,12,16,18,19,21,23-九烯 +
反应条件
samarium diiodide in tetrahydrofuran
1 h; Ambient temperature; Further byproducts given;
参考文献
Takahashi, Senji; Mori, Nobuo
→
反应条件
283-80-7 四环[14.2.2.24,7.210,13]二十四碳-4,6,10,12,16,18,19,21,23-九烯 +
反应条件
tetraphenylethylene in tetrahydrofuran
Heating; Yield given. Yields of byproduct given;
参考文献
Voegtle, Fritz; Kissener, Wolfram
→
反应条件
283-80-7 四环[14.2.2.24,7.210,13]二十四碳-4,6,10,12,16,18,19,21,23-九烯 +
反应条件
samarium diiodide in tetrahydrofuran
1 h; Ambient temperature; Further byproducts given;
参考文献
Takahashi, Senji; Mori, Nobuo
反应条件
tetrabutylammomium bromide; sodium hydroxide in dichloromethane; water
T=20°C; 3 h;
参考文献
Sahu, Krishnendu B.; Ghosh, Soma; Banerjee, Maitreyee; Maity, Arindam; Mondal, Shyamal; Paira, Rupankar; Saha, Pritam; Naskar, Subhendu; Hazra, Abhijit; Banerjee, Sukdeb; Samanta, Amalesh; Mondal, Nirup B.
反应条件
in tetrahydrofuran
0.5 h; Heating; Yield given;
参考文献
Ashton, Peter R.; Calcagno, Patrizia; Spencer, Neil; Harris, Kenneth D. M.; Philp, Douglas
