1,4-二(溴甲基)苯合成路线 （共 136 条）
反应条件
1: lead nitrate; water
2: concentrated sulfuric acid; KNO3 / 105 - 110 °C
View Scheme
参考文献
Loew
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 363
反应条件
alkali metal carbonate in N,N-dimethyl-formamide
Williamson synthesis;
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Suresh Kumar; Chen, Heidi; Jones, Susan Kilgore; Wenzler, Tanja; Barzcz, Todd; Werbovetz, Karl A.; Brun, Reto; Tidwell, Richard R.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3543 - 3551
反应条件
1: lead nitrate; water
2: HCl
View Scheme
参考文献
Loew
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 363
反应条件
samarium diiodide in tetrahydrofuran
1 h; -30 deg C to RT;
参考文献
Takahashi, Senji; Mori, Nobuo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 8 p. 2029 - 2032
反应条件
CeI2 in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Takahashi, Senji; Mori, Nobuo
Chemistry Letters, 1989 , p. 13 - 14
参考文献
Bobranski et al.
Arch. Immunol. Terap. dosw.Chem.Abstr., 1956 , vol. 4, p. 383,385
Arch. Immunol. Terap. dosw.Chem.Abstr., 1958 , p. 3156
反应条件
sodium hydroxide in 1,4-dioxane; water
T=20°C; 0.25 h;
参考文献
Adimurthy, Subbarayappa; Joshi, Girdhar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 6 p. 771 - 775
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 48 h;
参考文献
Rajakumar, Perumal; Murali, Venghatraghavan
Tetrahedron, 2004 , vol. 60, # 10 p. 2351 - 2360
反应条件
1: 150 °C
2: (i) NaH, (ii) /BRN= 471382/
View Scheme
参考文献
Tewari,R.S. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15B, p. 753 - 755
反应条件
potassium tert-butylate
参考文献
Martin et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 130
