4-氨甲基苯甲酸甲酯盐酸盐合成路线 （共 15 条）
反应条件
potassium hydroxide in tetrahydrofuran; water
T=20°C;
参考文献
Gutierrez-Nava, Manuel; Nierengarten, Helene; Masson, Patrick; Van Dorsselaer, Alain; Nierengarten, Jean-Francois
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3043 - 3046
反应条件
1: With N-ethyl-N,N-diisopropylamine in ethanol
3 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
pH=9; 1 h;
参考文献
METHYLGENE INC.
Patent: WO2005/92899 A1, 2005 ;
Location in patent: Page/Page column 65-66 ;
反应条件
sodium tetrahydroborate; triethylamine in dichloromethane
T=20°C; 6 h;
参考文献
Nagaoka; Maeda; Kawai; Nakashima; Oikawa; Shimoke; Ikeuchi; Kuwajima; Uesato
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 697 - 708
反应条件
1: With triethylamine in dichloromethane; isopropyl alcohol
T=20°C; 1 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane; isopropyl alcohol
T=20°C;
3: With sodium hydrogencarbonate in methanol; dichloromethane; water; isopropyl alcohol
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/152082 A1, 2009 ;
Location in patent: Page/Page column 53; 140 ;
WO 2009/152082 A1
反应条件
1: 91 percent / KOH / H2O; tetrahydrofuran / 20 °C
2: 93 percent / LiAlH4 / tetrahydrofuran / 0 °C
3: 63 percent / DCC; DMAP / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Gutierrez-Nava, Manuel; Nierengarten, Helene; Masson, Patrick; Van Dorsselaer, Alain; Nierengarten, Jean-Francois
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3043 - 3046
