2,4-二氢-3-巯基-5-甲基-4-苯基-3H-1,2,4-三唑合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=25°C; 5 h;
参考文献
Wang, Zhiwei; Wu, Baogen; Kuhen, Kelli L.; Bursulaya, Badry; Nguyen, Truc N.; Nguyen, Deborah G.; He, Yun
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4174 - 4177
反应条件
1: sodium / ethanol / 4 h 2: hydrazine hydrate / ethanol / 24 h / |Cooling 3: 14 h / 50 °C 4: sodium hydroxide / water / 2 h / |Reflux View Scheme
参考文献
Popiolek, Ukasz; Kosikowska, Urszula; Dobosz, Maria; Malm, Anna
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 3 p. 479 - 488
反应条件
dihydrogen peroxide; acetic acid in dichloromethane T=20°C; 3 h;
参考文献
Ivanova, Natalia V.; Sviridov, Sergey I.; Shorshnev, Sergey V.; Stepanov, Aleksander E.
Synthesis, 2006 , # 1 art. no. T05405SS, p. 156 - 160
反应条件
1: 83 percent / aq. H2O2; AcOH / CH2Cl2 / 3 h / 20 °C
2: 90 percent / o-xylene / 3 h / 125 °C
3: 77 percent / MnO2 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Ivanova, Natalia V.; Sviridov, Sergey I.; Shorshnev, Sergey V.; Stepanov, Aleksander E.
Synthesis, 2006 , # 1 art. no. T05405SS, p. 156 - 160
参考文献
Reynolds; Van Allan
Journal of Organic Chemistry, 1959 , vol. 24, p. 1478,1481
参考文献
Duffin; Kendall
Journal of the Chemical Society, 1959 , p. 3789,3794
