4-二甲基氨基-2-氧代-1,2-二氢-3-吡啶甲腈合成路线 （共 3 条）
反应条件
1.) toluene, reflux, 1 h, 2.) 150 deg C, 30 min; Yield given;
参考文献
Liebigs Annales, , # 10 p. 1501 - 1509
反应条件
1: With triethylamine; trichlorophosphate 3 h; Heating / reflux; 2: With sodium hydroxide in water T=0°C;
参考文献
Schering Corporation
Patent: US2007/72864 A1, 2007 ;
Location in patent: Page/Page column 22; 20 ;
US 20070072864 A1
反应条件
1: 73 percent / POCl3; triethylamine / 3 h / Heating
2: 71 percent / NH3 / methanol / 7 h / 120 °C
View Scheme
参考文献
Yakovlev; Romanova; Grizik; Kadushkin; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 11 p. 615 - 618
