P,P-二甲基膦酰乙酸叔丁酯合成路线 （共 5 条）
反应条件
in 2-MeTHF T=5 - 20°C;
参考文献
WO2009/81195 A1, ;
Page/Page column 29; 161-162 ;
WO 2009/081195 A1
反应条件
potassium iodide in acetonitrile T=25 - 70°C; 1.75 h;
参考文献
China Guangdong Nuclear Power Hoiding Corporation; Dayabay Nuclear Power Operations and Management Co., Ltd.; China Institute For Radiation Protection; DU, Jianxing; ZHANG, Dayong; BIAN, Shouli; LIU, Daohe; WU, Yukun; LI, Xianfeng; YANG, Lietang; KONG, Haixia; QIU, Dangui; SHI, Yingxia; GUO, Liangtian; WU, Zhenlong; HAN, Lihong
Patent: EP2581359 A1, 2013 ;
Location in patent: Paragraph 0053 ;
反应条件
1: 92 percent / t-BuOK / CH2Cl2 / 0 - 20 °C
2: 94 percent / Grubbs catalyst / CH2Cl2
View Scheme
参考文献
Moore, Joel D.; Sprott, Kevin T.; Hanson, Paul R.
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8123 - 8129
反应条件
1: tert-butyl (dimethoxyphosphoryl)acetate With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: pyridine-4-carbaldehyde in tetrahydrofuran
T=0 - 20°C; 19 h;
3: With hydrogen; palladium 10 on activated carbon in etanol
6 h;
参考文献
SCHERING AG
Patent: WO2006/8179 A2, 2006 ;
Location in patent: Page/Page column 29-30 ;
反应条件
phosphorus tribromide; potassium carbonate
1) H2O, 33 - 38 deg C, 1h, 2) Et2O, RT, 3h; Yield given. Multistep reaction;
参考文献
Giese; Linker
Synthesis, 1992 , # 1-2 p. 46 - 48
