6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛合成路线 （共 5 条）
反应条件
1: 2-amino-1-pyrroline hydrochloride With sodium methylate in ethanol T=20°C; 0.0833333 h; 2: 2-bromo-3-hydroxypropenal in ethanol T=20°C; 1 h; 3: With triethylamine in chloroform 3 h; Heating / reflux;
参考文献
WYETH
Patent: WO2003/93279 A1, 2003 ;
Location in patent: Page/Page column 62-63 ;
反应条件
1: 2-amino-1-pyrroline hydrochloride With sodium methylate in ethanol T=20°C; 0.0833333 h; 2: 2-bromo-3-propoxy-propenal in ethanol T=20°C; 1 h; 3: With triethylamine in chloroform 3 h; Heating / reflux;
参考文献
WYETH
Patent: WO2007/16134 A1, 2007 ;
Location in patent: Page/Page column 35 ;
反应条件
1: With sodium methylate in ethanol T=20°C; 1.08333 h; 2: With triethylamine in chloroform 3 h; Heating / reflux;
参考文献
WYETH
Patent: WO2003/93277 A1, 2003 ;
Location in patent: Page/Page column 80-81 ;
反应条件
triethylamine in dichloromethane 3 h; Heating / reflux;
参考文献
US2006/276445 A1, ;
Page/Page column 17 ;
反应条件
sodium methylate; triethylamine in ethanol; chloroform
