5,6-二氢-8H-咪唑并[2,1-c][1,4]恶嗪-3-甲醛合成路线 （共 5 条）
反应条件
1: 2-bromo-3-hydroxypropenal With toluene-4-sulfonic acid; isopropyl alcohol in cyclohexane
T=80°C;
2: morpholin-3-ylideneamine hydrochloride With sodium methylate in methanol; ethanol
T=20°C; 2 h;
3: With triethylamine in chloroform
2 h; Heating / reflux;
参考文献
WYETH
Patent: WO2003/93279 A1, 2003 ;
Location in patent: Page/Page column 65-66 ;
反应条件
1: 2-bromo-3-hydroxypropenal With toluene-4-sulfonic acid in cyclohexane; isopropyl alcohol
T=80°C;
2: morpholin-3-ylideneamine hydrochloride With sodium methylate in methanol; ethanol
T=20°C; 2 h;
3: With triethylamine in chloroform
2 h; Heating / reflux;
参考文献
WYETH
Patent: WO2003/93277 A1, 2003 ;
Location in patent: Page/Page column 93-94 ;
反应条件
1: With sodium methylate in methanol
T=20°C; 2 h;
2: With triethylamine in chloroform
2 h; Heating / reflux;
参考文献
Wyeth
Patent: US2006/276445 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: With sodium methylate in ethanol
T=20°C; 2 h;
2: With triethylamine in chloroform
2 h; Heating / reflux;
参考文献
WYETH
Patent: WO2007/16134 A1, 2007 ;
Location in patent: Page/Page column 37; 38 ;
反应条件
1: in acetonitrile
T=30 - 35°C; 2 - 2.5 h;
2: With potassium carbonate in acetonitrile
T=70°C; 0.25 - 0.5 h; Product distribution / selectivity;
参考文献
Wyeth
Patent: US2009/18332 A1, 2009 ;
Location in patent: Page/Page column 4; 13-14 ;
US 20090018332 A1
