(3R)-3-{[(苄氧基)羰基]氨基}-4-(羟基甲基)吡咯烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: potassium carbonate / toluene / 20 °C
2: H2 / Pd(OH)/C / 760 Torr
3: triethylamine / tetrahydrofuran / 0 °C
View Scheme
参考文献
Kati; Montgomery; Maring; Stoll; Giranda; Chen; Laver; Kohlbrenner; Norbeck
Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 9 p. 2563 - 2570
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C;
参考文献
Hanselmann, Roger; Zhou, Jiacheng; Ma, Philip; Confalone, Pat N.
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8739 - 8741
反应条件
1: diisobutylaluminum hydride / CH2Cl2 / -78 °C
2: potassium carbonate / toluene / 20 °C
3: H2 / Pd(OH)/C / 760 Torr
4: triethylamine / tetrahydrofuran / 0 °C
View Scheme
参考文献
Kati; Montgomery; Maring; Stoll; Giranda; Chen; Laver; Kohlbrenner; Norbeck
Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 9 p. 2563 - 2570
反应条件
1: sodium hydride / tetrahydrofuran / 0 °C
2: diisobutylaluminum hydride / CH2Cl2 / -78 °C
3: potassium carbonate / toluene / 20 °C
4: H2 / Pd(OH)/C / 760 Torr
5: triethylamine / tetrahydrofuran / 0 °C
View Scheme
参考文献
Kati; Montgomery; Maring; Stoll; Giranda; Chen; Laver; Kohlbrenner; Norbeck
Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 9 p. 2563 - 2570
反应条件
1: H2 / Pd(OH)2/C / methanol / 760 Torr
2: 375 mg / NaHCO3 / tetrahydrofuran; H2O / 20 °C
View Scheme
参考文献
Hanselmann, Roger; Zhou, Jiacheng; Ma, Philip; Confalone, Pat N.
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8739 - 8741
