叔丁基 4-(5-甲酰基-2-噻吩)哌嗪-1-羧酸合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide
T=130°C; 18 h;
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 107 ;
US 20080153812 A1
反应条件
in ethanol
T=20°C; 24 h;
参考文献
PIERRE FABRE MEDICAMENT; BEDJEGUELAL, Karim; RABOT, Remi; KALOUN, El Bachir; MAYER, Patrice; MARCHAND, Arnaud; RAHIER, Nicolas; SCHAMBEL, Philippe; BIENAYME, Hugues
Patent: WO2011/45344 A1, 2011 ;
Location in patent: Page/Page column 86 ;
WO 2011/045344 A1
反应条件
1: water / 48 h / Reflux
2: ethanol / 24 h / 20 °C
View Scheme
参考文献
PIERRE FABRE MEDICAMENT; BEDJEGUELAL, Karim; RABOT, Remi; KALOUN, El Bachir; MAYER, Patrice; MARCHAND, Arnaud; RAHIER, Nicolas; SCHAMBEL, Philippe; BIENAYME, Hugues
Patent: WO2011/45344 A1, 2011 ;
WO 2011/045344 A1
