BMIK 双(1-甲基-2-咪唑基)甲酮合成路线 （共 8 条）
反应条件
1.1: 83 percent / KOH; hydrazine hydrate / 4 h / 120 - 150 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -80 - -45 °C 2.2: 85 percent / tetrahydrofuran; hexane / -70 - 20 °C View Scheme
参考文献
Braussaud; Ruether; Cavell; Skelton; White
Synthesis, 2001 , # 4 p. 626 - 632
反应条件
potassium hydroxide; hydrazine hydrate T=120 - 150°C; 4 h;
参考文献
Braussaud; Ruether; Cavell; Skelton; White
Synthesis, 2001 , # 4 p. 626 - 632
反应条件
n-butyllithium in diethyl ether; hexane
T=-78 - -45°C; 1.5 h;
参考文献
Gorun, Sergiu M.; Papaefthymiou, Georgia C.; Frankel, Richard B.; Lippard, Stephen J.
Journal of the American Chemical Society, 1987 , vol. 109, # 14 p. 4244 - 4255
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=0°C; Metallation; 0.5 h;
2: N,N-dimethylcarbamoyl chloride in tetrahydrofuran; hexane
T=-50 - 0°C; Acylation; 3 h;
参考文献
Lucas; El Mehdi; Ho; Belanger; Breau
Synthesis, 2000 , # 9 p. 1253 - 1258
反应条件
n-butyllithium
1.) diethyl ether, RT, 2.) diethyl ether, from -60 deg C to RT, 3 h; Yield given. Multistep reaction;
参考文献
Canty, Allan J.; George, Edwin E.; Lee, Christopher V.
Australian Journal of Chemistry, 1983 , vol. 36, # 2 p. 415 - 418
反应条件
n-butyllithium
1) THF, hexane, -78 deg C, 1h, 2) 30 min; Yield given. Multistep reaction;
参考文献
Ngochindo, Raphael I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 6 p. 1645 - 1648
反应条件
n-butyllithium
1.) diethyl ether; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Canty, Allan J.; George, Edwin E.; Lee, Christopher V.
Australian Journal of Chemistry, 1983 , vol. 36, # 2 p. 415 - 418
反应条件
n-butyllithium
1) hexane, 2a) Et2O, -78 deg C, 2.4h, 2b) 0 deg C, 25 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ngochindo, Raphael I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 6 p. 1645 - 1648
