N-(3-碘-4-甲基苯基)-3-噻吩羧酰胺合成路线 （共 5 条）
反应条件
1: 3-thiophene-carboxylic acid With oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide
T=0 - 20°C;
2: 4-iodo-3-methylaniline With potassium carbonate; pyridine in dichloromethane; N,N-dimethyl-formamide
T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/147103 A2, 2007 ;
Location in patent: Page/Page column 131 ;
WO 2007/147103 A2
反应条件
oxalyl dichloride; potassium carbonate; pyridine; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 19 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/147109 A2, 2007 ;
Location in patent: Page/Page column 110-111 ;
WO 2007/147109 A2
反应条件
1: 3-thiophene-carboxylic acid With HATU in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: 3-iodo-4-methylphenylamine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/93248 A1, 2003 ;
Location in patent: Page/Page column 29-30 ;
WO 03/093248 A1
反应条件
1: 4-iodo-3-methylaniline With pyridine; potassium carbonate in dichloromethane
T=0°C; 1 h;
2: 3-thiophenecarboxylic acid chloride in dichloromethane
T=20°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/104915 A2, 2006 ;
Location in patent: Page/Page column 148 ;
WO 2006/104915 A2
反应条件
pyridine; potassium carbonate in dichloromethane
T=0 - 20°C; 19 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/104889 A2, 2006 ;
Location in patent: Page/Page column 123-124 ;
WO 2006/104889 A2
