3,3-二甲基-1-丁基酸酯合成路线 （共 65 条）
反应条件
F-DEAD-2; PPh2(p-C6H4-C2H4C8F17) in tetrahydrofuran
T=20°C; Mitsunobu reaction; 3 h;
参考文献
Dandapani, Sivaraman; Curran, Dennis P.
Journal of Organic Chemistry, 2004 , vol. 69, # 25 p. 8751 - 8757
参考文献
Matsunaga; Miyajima
Molecular crystals and liquid crystals, 1984 , vol. 104, # 3-4 p. 353 - 359
反应条件
1.1: 99.2 percent / PBr3; pyridine / 12 h / Heating
2.1: Mg / diethyl ether / 2 h / 20 °C
2.2: 43.9 percent / diethyl ether / 1 h / 20 °C
3.1: 44.8 percent / LiAlH4 / diethyl ether / 5 h / Heating
4.1: 54.4 percent / PBr3; pyridine / 12 h / Heating
View Scheme
参考文献
Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674
反应条件
in chloroform
T=80°C; 7.2 h;
参考文献
Nishiwaki, Nagatoshi; Nishida, Daisei; Ohnishi, Tetsuya; Hidaka, Fumie; Shimizu, Satoru; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8650 - 8656
反应条件
PPA
T=180 - 190°C; 3 h;
参考文献
Van Dyke Tiers, George
Acta Chemica Scandinavica, 1998 , vol. 52, # 10 p. 1223 - 1233
参考文献
Schulz; Sprung; Kroning
Pharmazie, 1983 , vol. 38, # 5 p. 310 - 313
参考文献
Schulz; Sprung; Kroning
Pharmazie, 1983 , vol. 38, # 5 p. 310 - 313
反应条件
pyridine
T=0°C; 4 h;
参考文献
Susumu, Kimihiro; Therien, Michael J.
Journal of the American Chemical Society, 2002 , vol. 124, # 29 p. 8550 - 8552
反应条件
1: pyridinium chlorochromate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
2: pyrrolidine; propionic acid / water; isopropyl alcohol / 45 °C
View Scheme
参考文献
Logan, Angus W.J.; Parker, Jeremy S.; Hallside, Michal S.; Burton, Jonathan W.
Organic Letters, 2012 , vol. 14, # 12 p. 2940 - 2943
反应条件
1: PBr3 / -10 °C
2: Na / ethanol / Heating
3: aq. KOH
4: 180 °C / (thermolysis)
View Scheme
参考文献
Bianchi,M. et al.
Gazzetta Chimica Italiana, 1974 , vol. 104, p. 273 - 286
