alpha-氧代[1,1'-联苯]-4-乙酸乙酯合成路线 （共 18 条）
反应条件
1: 4-bromo-1,1'-biphenyl With magnesium in tetrahydrofuran T=20°C; 0.5 - 0.666667 h; Heating / reflux; 2: oxalic acid diethyl ester in tetrahydrofuran T=-78 - 10°C; 1 h;
参考文献
UNIVERSITY OF CONNECTICUT
Patent: WO2008/13963 A2, 2008 ;
Location in patent: Page/Page column 96 ;
WO 2008/013963 A2
反应条件
1: 4-bromo-1,1'-biphenyl With magnesium in tetrahydrofuran 0.5 - 0.666667 h; Heating / reflux; 2: oxalic acid diethyl ester in tetrahydrofuran T=-78 - 10°C; 1 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
WO2009/52319 A1, ;
Page/Page column 140 ;
WO 2009/052319 A1
反应条件
aluminium trichloride in dichloromethane 3 h; Ambient temperature;
参考文献
Neidlein; Hofmann
Arzneimittel-Forschung, 1983 , vol. 33, # 5 p. 691 - 693
反应条件
1: 1-(biphenyl-4-yl)-2,2-dibromoethanone With dimethyl sulfoxide T=70 - 75°C; Inert atmosphere; 2: ethanol T=25 - 30°C; Inert atmosphere;
参考文献
Raghunadh, Akula; Meruva, Suresh Babu; Kumar, Nuka Anil; Kumar, Gudla Santosh; Rao, L. Vaikunta; Syamkumar
Synthesis, 2012 , vol. 2012, # 2 p. 283 - 289
反应条件
1: Pd(PPh3)4 / dioxane / 24 h / 95 °C / 775.7 Torr 2: 1) ozone, O2; 2) dimethyl sulfide / 1) MeOH, -78 deg C; 2) room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 10 p. 3114 - 3118
反应条件
water; hydrogen bromide; oxygen 20 h; Irradiation;
参考文献
Tada, Norihiro; Ban, Kazunori; Nobuta, Tomoya; Hirashima, Shin-Ichi; Miura, Tsuyoshi; Itoh, Akichika
Synlett, 2011 , # 10 art. no. U01411ST, p. 1381 - 1384
反应条件
in tetrahydrofuran T=-78°C; 1 h; Schlenk techniqueInert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 47 p. 122414 - 122417
Angew. Chem., , p. 12640 - 12643,4
反应条件
2: Abspaltung der Carboxylgruppe View Scheme
参考文献
Rousset
Bulletin de la Societe Chimique de France, 1897 , vol. <3> 17, p. 814
反应条件
1: platinum palladium-catalyst; aqueous ethanol / Hydrogenation.Behandlung des Reaktionsprodukts mit warmer aethanol. Kalilauge 2: red phosphorus; iodine; acetic acid View Scheme
参考文献
Blicke; Grier
Journal of the American Chemical Society, 1943 , vol. 65, p. 1725,1727
反应条件
1: sodium carbonate; aqueous ethanol
2: diethyl ether
3: red phosphorus; iodine; acetic acid
View Scheme
参考文献
Blicke; Grier
Journal of the American Chemical Society, 1943 , vol. 65, p. 1725,1727
