4-甲氧基-2-甲基苯甲酸合成路线 （共 52 条）
反应条件
1: 1-bromo-4-methoxy-2-methylbenzene With magnesium in tetrahydrofuran T=40 - 60°C; 3.5 h; 2: carbon dioxide in tetrahydrofuran T=-10 - 30°C; 3: With hydrogenchloride; water in tetrahydrofuran
参考文献
WO2006/76246 A2, ;
Page/Page column 147 ;
WO 2006/076246 A2
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Lehmann, Fredrik; Currier, Erika A.; Olsson, Roger; Ma, Jian-Nong; Burstein, Ethan S.; Hacksell, Uli; Luthman, Kristina
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4844 - 4854
反应条件
sodium chlorite; aminosulfonic acid in tetrahydrofuran; water Ambient temperature;
参考文献
Hauser, Frank M.; Ellenberger, Suzanne R.
Synthesis, 1987 , # 8 p. 723 - 724
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran T=-78 - 20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
oxygen; palladium diacetate in acetic acid T=70°C; P=760.051 Torr; 15 h; Title compound not separated from byproducts.;
参考文献
Chemical Communications, , # 4 p. 486 - 488
反应条件
1: in tetrahydrofuran T=20°C; P=3000.3 Torr; gas-liquid flow reactor assembly; 2: With polymer-supported sulfonic acid in tetrahydrofuran
参考文献
Polyzos, Anastasios; O'Brien, Matthew; Petersen, Trine P.; Baxendale, Ian R.; Ley, Steven V.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 5 p. 1190 - 1193
反应条件
sodium hydroxide; bromine in water 2 h; Ambient temperature;
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
oxone; sodium hydrogencarbonate in water; acetonitrile T=20°C; 7.5 h;
参考文献
Vijay Kumar; Prakash Reddy; Sridhar; Srinivas; Rama Rao
Synlett, 2009 , # 5 p. 739 - 742
反应条件
1: 92 percent / copper(II) sulfate pentahydrate, potassium peroxydisulfate / acetonitrile; H2O / 0.5 h / Heating 2: 90 percent / sulfamic acid, sodium chlorite / tetrahydrofuran; H2O / Ambient temperature View Scheme
参考文献
Synthesis, , # 8 p. 723 - 724
反应条件
1: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 2: 280 mg / 50percent NaOH / ethanol / 2 h / Heating 3: air oxidation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 13 p. 2730 - 2734
