4-甲氧基-2-甲基苯甲酸合成路线 （共 52 条）
反应条件
1: 78 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2 / 0 °C 2: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 3: 280 mg / 50percent NaOH / ethanol / 2 h / Heating 4: air oxidation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 13 p. 2730 - 2734
反应条件
1: 90 percent / pyridinium chlorochromate / oxidation 2: 78 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2 / 0 °C 3: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 4: 280 mg / 50percent NaOH / ethanol / 2 h / Heating 5: air oxidation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 13 p. 2730 - 2734
反应条件
oxygen; Titanium(IV) oxide; silver sulphate in acetonitrile 2 h; Ambient temperatureIrradiation;
参考文献
Tetrahedron Letters, , vol. 33, # 37 p. 5437 - 5440
反应条件
1: 1.) AgNO3, NaHCO3, 2.) triethylamine / 1.) DMSO, room temp, 1 h, 2.) 15 min 2: n-bromosuccinimide / azobisisobutyronitrile / CCl4 / 0.5 h / Heating View Scheme
参考文献
Synthesis, , # 6 p. 504 - 506
反应条件
1: 280 mg / 50percent NaOH / ethanol / 2 h / Heating 2: air oxidation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 13 p. 2730 - 2734
反应条件
hydrogenchloride Ambient temperature;
参考文献
Journal of the American Chemical Society, , vol. 109, p. 7824
反应条件
1: 1N NaOH / CH2Cl2 / 5 h / Ambient temperature 2: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine (TMEDA) / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 19 p. 3566 - 3572
反应条件
1: n-BuLi, MgBr2 / tetrahydrofuran; diethyl ether; hexane / -78 °C / warming to room temperature 2: NaOH / H2O 3: air View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 5 p. 922 - 924
反应条件
1: 42 percent / AlCl3 2: 64 percent / Br2, aq. NaOH / 0.5 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1798 - 1806
反应条件
sodium hydroxide; potassium permanganate
参考文献
Journal of Organic Chemistry, , vol. 26, p. 2310 - 2316
