4-甲氧基-2-甲基苯甲酸合成路线 （共 52 条）
反应条件
thionyl chloride T=20°C; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/5998 A1, 2009 ;
Location in patent: Page/Page column 214 ;
反应条件
sodium hydrogencarbonate
参考文献
Ruchelman, Alexander L.; Man, Hon-Wah; Zhang, Weihong; Chen, Roger; Capone, Lori; Kang, Jian; Parton, Anastasia; Corral, Laura; Schafer, Peter H.; Babusis, Darius; Moghaddam, Mehran F.; Tang, Yang; Shirley, Michael A.; Muller, George W.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 360 - 365
反应条件
potassium permanganate
参考文献
Chemische Berichte, , vol. 12, p. 818,821
反应条件
1: KMnO4; alkali 2: potassium hydroxide / durch Schmelzen View Scheme
参考文献
Chemische Berichte, , vol. 12, p. 818,821
反应条件
boron tribromide in dichloromethane T=20°C; 5 h;
参考文献
Lang, Martin; Muehlbauer, Andrea; Graef, Claudia; Beyer, Juergen; Lang-Fugmann, Susanne; Polborn, Kurt; Steglich, Wolfgang
European Journal of Organic Chemistry, 2008 , # 5 p. 816 - 825
反应条件
1: With thionyl chloride T=80°C; 0.5 h; 2: With ammonium hydroxide in tetrahydrofuran; water T=0°C; 1 h; Cooling with ice;
参考文献
Leonard, Kristi Anne; Zhang, Yan; Tounge, Brett Andrew; Wang, Aihua; Hawkins, Michael; Jackson, Paul Francis; Barbay, Joseph Kent; Maharoof, Umar S.M.
Patent: US2012/129872 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
thionyl chloride Heating;
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
1: 73 percent / conc. H2SO4 / 24 h / Heating 2: 73 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 2.5 h / Heating View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1: SOCl2 / 2 h / Heating
2: Et3N / CH2Cl2 / 2 h
3: 37percent aq. HCl / 0.5 h
4: 1.) MeCN, reflux, 1 h, 2.) 110 deg C, 2 h
5: 0.17 h / 200 °C
View Scheme
参考文献
Omodei-Sale, Amedeo; Consonni, Pietro; Galliani, Giulio
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1187 - 1192
反应条件
in thionyl chloride; water; ethyl acetate
参考文献
Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael
Patent: US2013/115190 A1, 2013 ;
Location in patent: Page/Page column ;
