Beta-氧代-环己烷丙腈合成路线 （共 6 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=75°C; 4 h;
参考文献
Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael
Patent: US2012/184542 A1, 2012 ;
Location in patent: Page/Page column 112 ;
US 20120184542 A1
反应条件
1: anhydrous cyanoacetic acid With [2,2']bipyridinyl; n-butyllithium; magnesium sulfate in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: cyclohexane carboxylic acid chloride in tetrahydrofuran; methanol; hexane T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; methanol; hexane; water
参考文献
Nowill, Randall W.; Patel, Trisha J.; Beasley, David L.; Alvarez, Jose A.; Jackson III, Elizah; Hizer, Todd J.; Ghiviriga, Ion; Mateer, Scott C.; Feske, Brent D.
Tetrahedron Letters, 2011 , vol. 52, # 19 p. 2440 - 2442
反应条件
sodium hydride in tetrahydrofuran
参考文献
Journal of Heterocyclic Chemistry, , vol. 26, p. 1575 - 1578
反应条件
hydrazine hydrate in ethanol 2.5 h; Heating;
参考文献
Larsen, Scott D.; Spilman, Charles H.; Bell, Frank P.; Dinh, Dac M.; Martinborough, Esther; Wilson, Gracella J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1721 - 1727
反应条件
1: 74 percent / NaN3; AlCl3 / tetrahydrofuran / 216 h / Heating
2: 69 percent / Pb(OAc)4 / dioxane / 0.33 h / 10 - 15 °C
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参考文献
Fetter; Nagy; Giang; Kajtar-Peredy; Rockenbauer; Korecz; Czira
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 1131 - 1139
反应条件
hydroxylamine in ethanol; water
参考文献
Buchanan, John L.; Chaffee, Stuart; Harmange, Jean-Christophe; Novak, Perry M.; Zhu, Xiaotian
Patent: US2003/125346 A1, 2003 ;
