反式-4-氨基环己烷羧酸甲酯合成路线 （共 11 条）
反应条件
1: 531 g / triethylamine / CHCl3 / 5 h / 20 °C 2: 301 g / lithium aluminum hydride / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Kanuma, Kosuke; Omodera, Katsunori; Nishiguchi, Mariko; Funakoshi, Takeo; Chaki, Shigeyuki; Nagase, Yasuko; Iida, Izumi; Yamaguchi, Jun-ichi; Semple, Graeme; Tran, Thuy-Anh; Sekiguchi, Yoshinori
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3307 - 3319
反应条件
1: 190 - 200 °C / Bei schnellem Erhitzen 2: sodium amide; toluene 3: lithium alanate; diethyl ether 4: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Werner; Ricca
Journal of the American Chemical Society, 1958 , vol. 80, p. 2733,2736
反应条件
T=190 - 200°C; Bei schnellem Erhitzen;
参考文献
Werner; Ricca
Journal of the American Chemical Society, 1958 , vol. 80, p. 2733,2736
反应条件
triethylamine in dichloromethane T=20°C; 2.16667 h; Cooling with ice;
参考文献
Shionogi and Co., Ltd.
Patent: US2010/273841 A1, 2010 ;
Location in patent: Page/Page column 21 ;
US 20100273841 A1
反应条件
1.1: triethylamine / methanol / 10 - 20 °C 2.1: ethanol; calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 5 - 20 °C 2.2: 10 °C / pH 11 View Scheme
参考文献
NOVARTIS AG; ATKINSON, Benjamin; BEATTIE, David; CULSHAW, Andrew James; DALE, James; DEVEREUX, Nicholas James; MCKENNA, Jeffrey
Patent: WO2011/92293 A2, 2011 ;
WO 2011/092293 A1
反应条件
1: 190 - 200 °C / Bei schnellem Erhitzen
2: sodium amide; toluene
3: aqueous HCl
View Scheme
参考文献
Werner; Ricca
Journal of the American Chemical Society, 1958 , vol. 80, p. 2733,2736
反应条件
1: aq. NaOH
2: NaNO2, HCO2H
View Scheme
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
反应条件
2: NaNO2, HCO2H
View Scheme
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
参考文献
Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290
