5-甲氧基-3-氧代戊酸甲酯合成路线 （共 6 条）
反应条件
pyridine in dichloromethane T=0 - 20°C;
参考文献
ABBVIE DEUTSCHLAND GMBH and CO. KG; HAUPT, Andreas
Patent: WO2014/64038 A1, 2014 ;
Location in patent: Page/Page column 45; 46 ;
反应条件
aluminium amalgam; water; trifluoroacetic acid in tetrahydrofuran T=33°C; 26 h;
参考文献
Sanchez, Ignacio H.; Larraza, Maria Isabel; Brena, Francisco Kuri; Cruz, Adrian; Sotelo, Octavio; Flores, Humberto J.
Synthetic Communications, 1986 , vol. 16, # 3 p. 299 - 308
反应条件
copper; zinc in tetrahydrofuran 0.5 h; Heating;
参考文献
Richert; Wessels; Muller; Kisters; Benninghaus; Goetz
Journal of Medicinal Chemistry, 1994 , vol. 37, # 17 p. 2797 - 2807
反应条件
potassium hydroxide in methanol left overnight;
参考文献
Akhrem, A. A.; Chernov, Yu. G.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 2 p. 255 - 256
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 2 p. 288 - 289
参考文献
Synthesis, , p. 622 - 623
反应条件
(i) NaH, nBuLi, THF, (ii) /BRN= 505943/; Multistep reaction;
参考文献
Journal of the Chemical Society, Chemical Communications, , p. 91 - 92
