8-甲氧基喹唑啉-2,4(1h,3h)-二酮合成路线 （共 7 条）
反应条件
1: POCl3; N,N-dimethylaniline / 16 h / Heating 2: 388 mg / aq. NaOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
反应条件
N,N-dimethyl-aniline; trichlorophosphate 5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773
反应条件
sodium hydroxide in water; acetic acid
参考文献
SmithKline Beecham Intercredit B.V.
Patent: EP322133 B1, 1991 ;
Title/Abstract Full Text Show Details
SmithKline Beecham Intercredit B.V.
Patent: EP322133 A1, 1989 ;
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethanol / 0.17 h / 2625.2 Torr / Ambient temperature
2: 58 percent / aq. AcOH / 2 h
View Scheme
参考文献
Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773
参考文献
Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1921 , vol. 119, p. 1431
