8-氯喹唑啉-2,4(1h,3h)-二酮合成路线 （共 4 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate 16 h; Heating;
参考文献
Carna Biosciences Inc.; Crystalgenomics, Inc.
Patent: EP2226315 A1, 2010 ;
Location in patent: Page/Page column 33 ;
反应条件
urea in water; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
反应条件
in 1-methyl-pyrrolidin-2-one
T=180 - 190°C; 4 h;
参考文献
Carna Biosciences Inc.; Crystalgenomics, Inc.
Patent: EP2226315 A1, 2010 ;
Location in patent: Page/Page column 32-33 ;
反应条件
1: POCl3; N,N-dimethylaniline / 16 h / Heating
2: aq. NaOH / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
