2-氯-5-甲基-4-硝基苯甲醚合成路线 （共 13 条）
反应条件
hydrogen; nickel in methanol
参考文献
Kolbah; Blazevic; Hannoun; et al.
Helvetica Chimica Acta, 1977 , vol. 60, # 1 p. 265 - 283
反应条件
1: 80 percent / dimethylformamide / 48 h / Heating
2: 54 percent / powdered iron / ethanol; acetic acid / 3 h / Heating
View Scheme
参考文献
Batandier; Marsura; Luu-Duc
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 227 - 230
反应条件
1: dimethylformamide / 6 h / 130 °C
2: H2 / Raney-Ni / 2896.03 Torr
3: diethyl ether / 0.5 h / 0 °C
4: NH3 / toluene
5: 1.) (CH3)2S*BH3, 2.) aq. HCl / 1.) THF, reflux, 30 min, 2.) 100 deg C, 20 min
6: pyridine / ethyl acetate / Ambient temperature
View Scheme
参考文献
Huegel, Helmut M.
Synthesis, 1983 , # 11 p. 935 - 936
