1: 3-methoxybromobenzene With n-butyllithium in diethyl ether; hexane
T=-78 - 0°C; 2 h;
2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; diethyl ether; hexane
T=0°C; 2 h; Further stages;
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=25°C; 16 h;
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
