1-(3-氨基丙基)-1-(4-氟苯基)-1,3-二氢-5-异苯并呋喃甲腈合成路线 （共 6 条）
反应条件
1: 1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile With potassium tert-butylate in dimethyl sulfoxide T=25 - 65°C; 0.416667 - 0.5 h; 2: 1-chloro-3-aminopropane in dimethyl sulfoxide T=25 - 45°C; 1 - 1.16667 h; 3: With hydrogenchloride in water pH=2 - 3; Product distribution / selectivity;
参考文献
WO2005/47274 A1, ;
Page/Page column 26-27 ;
反应条件
1: 1-Amino-3-chloro-propane hydrochloride With sodium hydroxide in water; toluene 0.166667 - 0.25 h; 2: 1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile With potassium tert-butylate in dimethyl sulfoxide; toluene T=40 - 45°C; 1 h;
参考文献
Organic Process Research and Development, , vol. 13, # 1 p. 34 - 37
反应条件
1.1: 2.44 g / dimethylformamide / 6 h / Heating 2.1: sodium methylsulfinylmethide / dimethylsulfoxide; various solvent(s) / 0.33 h 2.2: dimethylsulfoxide; various solvent(s) / 1 h / 20 °C 3.1: 4.11 g / aq. HCl View Scheme
参考文献
Synthetic Communications, , vol. 37, # 6 p. 901 - 908
反应条件
1.1: sodium methylsulfinylmethide / dimethylsulfoxide; various solvent(s) / 0.33 h 1.2: dimethylsulfoxide; various solvent(s) / 1 h / 20 °C 2.1: 4.11 g / aq. HCl View Scheme
参考文献
Synthetic Communications, , vol. 37, # 6 p. 901 - 908
反应条件
in water T=95 - 100°C; 12 h; Heating / reflux;
参考文献
DR. REDDY'S LABORATORIES, INC.; DR. REDDY'S LABORATORIES LTD.
Patent: WO2005/47274 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
(2R,3R)-(-)-di-O-(p-toluoyl)-tartaric acid in acetonitrile T=20 - 65°C; 0.75 - 1 h;
参考文献
DR. REDDY'S LABORATORIES, INC.; DR. REDDY'S LABORATORIES LTD.
Patent: WO2005/47274 A1, 2005 ;
Location in patent: Page/Page column 27-28 ;
