1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C
1.2: 16.5 h / -78 - 20 °C
2.1: hydrazine hydrate; acetic acid / ethanol / 16 h / Reflux
3.1: ethanol; sodium / 16 h / Reflux
3.2: pH 3
4.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / Reflux
View Scheme
参考文献
Liotta, Dennis C.; Snyder, James P.; Jogalekar, Ashutosh S.; Barrett, Anthony G.M.; Fuchter, Matthew John; Cook, Matthew J.; Kroll, Sebastian H.B.
Patent: US2012/41198 A1, 2012 ;
US 20120041198 A1
1: HCl(g) / 18 h / 25 °C
2: NH3 / ethanol / 72 h / 25 °C
View Scheme
参考文献
Moore, William M.; Webber, R. Keith; Fok, Kam F.; Jerome, Gina M.; Kornmeier, Christine M.; Tjoeng, Foe S.; Currie, Mark G.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 9 p. 1559 - 1564
