1: 4-nitro-aniline; 3-chloropropanoyl chloride With triethylamine in tetrahydrofuran
T=20°C; 2.3 h; Cooling with ice;
2: pyrrolidine in tetrahydrofuran
T=20°C; 14 h; Cooling with ice;
参考文献
Lombardo, Caterina M.; Welsh, Sarah J.; Strauss, Sandra J.; Dale, Aaron G.; Todd, Alan K.; Nanjunda, Rupesh; Wilson, W. David; Neidle, Stephen
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5984 - 5988