反应条件
1: sodium t-butanolate; 4-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 3 h / 100 °C 2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 16 h / 100 °C View Scheme
参考文献
GLAXO WELLCOME MANUFACTURING PTE LTD; CHEN, Deborah, W.; DUNCAN, Sarah; KING, Nigel, Paul; LEE, Kiew, Ching; MAK, Sing, Yeung; RIVERS, Dean, Andrews
Patent: WO2012/170752 A1, 2012 ;
WO 2012/170752 A1