反应条件
1.1: N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 - 25 °C
1.2: 4 h / 60 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 - 25 °C
3.1: trichlorophosphate / dichloromethane / 20 - 25 °C
4.1: 2 h / Reflux
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon, H.; DAVIES, Robert, J.; PIERCE, Albert, C.; WANG, Jian; NANTHAKUMAR, Suganthini; CAO, Jingrong; BANDARAGE, Upul, K.; KRUEGER, Elaine; TIRAN, Amaud, Le; LIAO, Yusheng; MESSERSMITH, David; COLLIER, Philip, N.; GREY, Ronald; O'DOWD, Hardwin; HENDERSON, James, A.; GRILLOT, Anne-Laure
Patent: WO2011/87776 A1, 2011 ;
WO 2011/087776 A1