3,5-二溴吡啶合成路线

参考文献

NOVARTIS AG
Patent: WO2008/34600 A1, 2008 ;
Location in patent: Page/Page column 26 ;

191161-15-6

参考文献

Wei, Zhi-Liang; Xiao, Yingxian; Yuan, Hongbin; Baydyuk, Maryna; Petukhov, Pavel A.; Musachio, John L.; Kellar, Kenneth J.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1721 - 1724

625-92-33,5-二溴吡啶

212332-40-63-溴-5-异丙氧基吡啶

参考文献

TARGACEPT, INC.
Patent: WO2006/53039 A2, 2006 ;
Location in patent: Page/Page column 42 ;

625-92-33,5-二溴吡啶+

12775-96-1+

67-63-0异丙醇

212332-40-63-溴-5-异丙氧基吡啶

参考文献

Bencherif; Merouane; Lippiello; Patrick Michael
Patent: US5811442 A1, 1998 ;

625-92-33,5-二溴吡啶+

67-63-0异丙醇

212332-40-63-溴-5-异丙氧基吡啶

参考文献

Leblanc, Catherine; Pulz, Robert Alexander; Stiefl, Nikolaus Johannes
Patent: US2009/181941 A1, 2009 ;
Location in patent: Page/Page column 49 ;

625-92-33,5-二溴吡啶+

6831-82-9异丙醇钾

212332-40-63-溴-5-异丙氧基吡啶

参考文献

Breining, Scott R.; Melvin, Matt; Bhatti, Balwinder S.; Byrd, Gary D.; Kiser, Melanie N.; Hepler, Christopher D.; Hooker, Dawn N.; Zhang, Jenny; Reynolds, Leslie A.; Benson, Lisa R.; Fedorov, Nikolai B.; Sidach, Serguei S.; Mitchener, J. Pike; Lucero, Linda M.; Lukas, Ronald J.; Whiteaker, Paul; Yohannes, Daniel
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9929 - 9945

288-32-4咪唑+

625-92-33,5-二溴吡啶

263868-66-2

参考文献

PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 128 ;
WO 2009/155527 A2

288-32-4咪唑+

625-92-33,5-二溴吡啶

263868-66-2

参考文献

Abbott Laboratories
Patent: US6054435 A1, 2000 ;

625-92-33,5-二溴吡啶+

6165-69-13-噻吩硼酸

286007-27-03-溴-5-(3-甲基噻吩-2-基)吡啶

参考文献

Fraley, Mark E.; Arrington, Kenneth L.; Hambaugh, Scott R.; Hoffman, William F.; Cunningham, April M.; Young, Mary Beth; Hungate, Randall W.; Tebben, Andrew J.; Rutledge, Ruth Z.; Kendall, Richard L.; Huckle, William R.; McFall, Rosemary C.; Coll, Kathleen E.; Thomas, Kenneth A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 18 p. 2973 - 2976

625-92-33,5-二溴吡啶+

6165-69-13-噻吩硼酸+

64-17-5乙醇

286007-27-03-溴-5-(3-甲基噻吩-2-基)吡啶

参考文献

Miller, Craig Harrison; Dull, Gary Maurice; Miao, Lan; Lynm, Dwo; Schmitt, Jeffrey Daniel; Clark, Thomas Jeffrey
Patent: US2002/13309 A1, 2002 ;

Title/Abstract Full Text Show Details
Targacept, Inc.
Patent: US6852721 B2, 2005 ;