反应条件
1: 1.) K2CO3, 2.) Cu, CuI / 1.) DMF, 120 deg C, 10 min, 2.) DMF, reflux, 50 h
2: 1.) 50percent polyphosphoric acid, 2.) pyridine / 1.) 120 deg C, 3 h, 2.) reflux, 16 h
3: 87 percent / 56percent HI / 4 h / Heating
4: 92 percent / pyridine / 1.5 h / 50 °C
5: 46 percent / 5 N aq. acetic acid / 72 h / 70 °C
6: 88 percent / 5 N aq. KOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Archer; Zayed; Rej; Rugino
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1240 - 1246
