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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
62501-71-7
合成路线
(共 5 条)
62501-71-7
→
反应条件
98572-00-0
(S)-2-羟甲基-1,4-苯并二恶烷
反应条件
palladium 10 on activated carbon; hydrogen in methanol 8 h;
参考文献
Tetrahedron Letters, , vol. 54, # 48 p. 6420 - 6422
62501-71-7
→
反应条件
62501-72-8
(R)-2-(羟基甲基)-1,4-苯并二噁烷
反应条件
hydrogen; palladium on activated charcoal
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
62501-71-7
→
反应条件
860173-98-4
(R)-(2,3-二氢-苯并[1,4]二噁英-2-基)-哌嗪-1-甲酮
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 8 h 2: potassium hydroxide; potassium permanganate / water; acetone / 0.5 h / 0 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran; dichloromethane / 0 °C 4: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
62501-71-7
→
反应条件
46049-48-3
(R)-2,3-二氢-1,4-苯并二恶烷-2-甲胺
反应条件
1: H2 / Pd/C 2: pyridine / 0 °C 3: dimethylformamide / Heating 4: NH2-NH2*H2O / 2-methoxy-ethanol / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
62501-71-7
→
反应条件
401941-54-6
(S)-1,4-苯并二噁烷-2-羧基哌嗪
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 8 h 2: potassium hydroxide; potassium permanganate / water; acetone / 0.5 h / 0 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran; dichloromethane / 0 °C 4: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422