(R)-2-(羟基甲基)-1,4-苯并二噁烷合成路线 （共 33 条）
反应条件
1: NaIO4 / methanol; H2O 2: NaBH4 / methanol; H2O View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 10 p. 1965 - 1968
反应条件
1: 1.) APTS, 2.) Et3N / 1.) reflux 2: 1.) H2, 2.) LiAlH4 / 1.) Pd/C / 1.) MeOH, 2.) Et2O, reflux View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 5, # 4 p. 535 - 536
反应条件
1: 30 percent / HBr / 0 - 35 °C 2: 79 percent / NaOH / methanol; H2O / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 30 p. 3671 - 3674
反应条件
1: H2, Pd/C / methanol / 12 h / Ambient temperature 2: 30 percent / HBr / 0 - 35 °C 3: 79 percent / NaOH / methanol; H2O / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 30 p. 3671 - 3674
反应条件
1: 1.8 g / lipase Amano PS / 3.5 h / 37 °C 2: 93 percent / 5N aq. KOH / methanol / 1 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 1 p. 57 - 60
反应条件
1: whole cells of Arthrobacter sp. ABL MTCC No. 5125 lipase / aq. phosphate buffer; di-isopropyl ether / 2 h / 25 °C / pH 7.1 2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 22-23 p. 1615 - 1623
反应条件
1: pyridine / 0 °C 2: H2 / Pd/C 3: H2 / Pd/C View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: H2 / Pd/C 2: H2 / Pd/C View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: 2 h / Heating 2: 1.) NaIO4, 2.) NaBH4 / 1.) ethanol, water, 10 min, 2.) ethanol, water, 10 min View Scheme
参考文献
Heterocycles, , vol. 23, # 8 p. 2005 - 2012
反应条件
sodium tetrahydroborate; sodium periodate 1.) ethanol, water, 10 min, 2.) ethanol, water, 10 min; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 23, # 8 p. 2005 - 2012
