2-氯-3-(4-(2-甲基-2-苯基丙氧基)苯基)丙酸乙酯合成路线 （共 11 条）
反应条件
1: 29.1 g / 25percent NaOH/H2O / methanol 3: 360 mg / 20percent HCl / 4 h / Ambient temperature 4: 220 mg / BBr3 / CH2Cl2 / 0.33 h / Ambient temperature 5: 200 mg / NaN3 / dimethylsulfoxide; H2O / 3 h / 90 °C 6: 1.) H2, 2.) HCl/Et2O / 1.) 10percent Pd/C / 1.) ethanol, 1 atm, r.t. View Scheme
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
hydrogenchloride; sodium nitrite in water; acetone
参考文献
Takeda Chemical Industries
Patent: US4080505 A1, 1978 ;
反应条件
1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C
2: H2 / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature
3: 1.) 33percent NaNO2/H2O, conc. HCl, ethyl acrylate, 2.) Cu2O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h
View Scheme
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
1: H2 / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature
2: 1.) 33percent NaNO2/H2O, conc. HCl, ethyl acrylate, 2.) Cu2O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h
View Scheme
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C
2: H2 / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature
3: 1.) 33percent NaNO2/H2O, conc. HCl, ethyl acrylate, 2.) Cu2O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h
View Scheme
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
copper(I) oxide; hydrogenchloride; water; ethyl acrylate; sodium nitrite
1.) acetone, ice cooling, 2.) 40 deg C, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
copper(I) oxide; hydrogenchloride; water; sodium nitrite
1.) acetone, ice cooling, 2.) 40 deg C, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
(i) NaNO2, aq. HCl, acetone, (ii) /BRN= 773866/, Cu2O; Multistep reaction;
参考文献
Takeda
Patent: DE2625163 , 1976 ;
Chem.Abstr., 1977 , vol. 86, # 171117
反应条件
thiourea in sulfolane; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4287200 A1, 1981 ;
反应条件
1: 75 percent / NaOAc / ethanol / 16 h / Heating
2: 83.3 percent / 6N HCl / tetrahydrothiophene 1,1-dioxide / 5 h / 110 °C
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
