P=0.03 Torr; 4 h; Heating;

1: 98 percent / Cu-powder / acetonitrile / 50 h / Heating 2: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 3: 67 percent / 4 h / 0.03 Torr / Heating View Scheme

1: 88 percent / CH2Cl2 / 2 h / Ambient temperature 2: 82 percent / SOCl2 3: 1) 1.6 N BuLi / 1) ether, hexane, -78 deg C, 15 min, 2) ether 4: 98 percent / Cu-powder / acetonitrile / 50 h / Heating 5: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 6: 67 percent / 4 h / 0.03 Torr / Heating View Scheme

1: 97 percent 2: 88 percent / CH2Cl2 / 2 h / Ambient temperature 3: 82 percent / SOCl2 4: 1) 1.6 N BuLi / 1) ether, hexane, -78 deg C, 15 min, 2) ether 5: 98 percent / Cu-powder / acetonitrile / 50 h / Heating 6: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 7: 67 percent / 4 h / 0.03 Torr / Heating View Scheme

1: 1) 1.6 N BuLi / 1) ether, hexane, -78 deg C, 15 min, 2) ether 2: 98 percent / Cu-powder / acetonitrile / 50 h / Heating 3: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 4: 67 percent / 4 h / 0.03 Torr / Heating View Scheme

1: 82 percent / SOCl2 2: 1) 1.6 N BuLi / 1) ether, hexane, -78 deg C, 15 min, 2) ether 3: 98 percent / Cu-powder / acetonitrile / 50 h / Heating 4: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 5: 67 percent / 4 h / 0.03 Torr / Heating View Scheme

1: 94 percent / NaOH / methanol; H2O / 16 h, RT; 45 min, reflux 2: 67 percent / 4 h / 0.03 Torr / Heating View Scheme