7-甲氧基-9h-吡啶并[3,4-b]吲哚合成路线 （共 5 条）
反应条件
palladium 10 on activated carbon in pyridine; xylene
5 h; Heating / reflux;
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1209158 A1, 2002 ;
Location in patent: Page 22 ;
EP 1209158 A1
反应条件
1: With sodium acetate
Pictet-Spengler reaction; pH=4.5 - 4.8;
2: With hydrogenchloride
Heating;
3: With palladium on activated charcoal in xylene
Heating;
参考文献
Castro, Alfredo C.; Dang, Luan C.; Soucy, Francois; Grenier, Louis; Mazdiyasni, Hormoz; Hottelet, Maria; Parent, Lana; Pien, Christine; Palombella, Vito; Adams, Julian
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2419 - 2422
反应条件
sodium hydroxide
T=150°C; im Rohr;
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: hydrogenchloride / methanol / 20 °C
3: manganese(IV) oxide; 5 Pd(II)/C(eggshell) / N,N-dimethyl-formamide / 150 °C / Microwave irradiation
View Scheme
参考文献
Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis; Liu, Ji-Feng; Lin, Xiangjie; Auerbach, Ken; Ray, Soumya S.; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2015 - 2019
反应条件
1: hydrogenchloride / methanol / 20 °C
2: manganese(IV) oxide; 5 Pd(II)/C(eggshell) / N,N-dimethyl-formamide / 150 °C / Microwave irradiation
View Scheme
参考文献
Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis; Liu, Ji-Feng; Lin, Xiangjie; Auerbach, Ken; Ray, Soumya S.; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2015 - 2019
