(9CI)-1H-苯并咪唑-2-硫脲合成路线 （共 5 条）
反应条件
hydrogenchloride in 1,4-dioxane
48 h; Heating / reflux;
参考文献
Sireen AG
Patent: EP1555264 A1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
in ethanol
22 h; Heating;
参考文献
Schiffmann, Rolf; Neugebauer, Alexander; Klein, Christian D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 511 - 522
反应条件
1: in acetonitrile
T=20°C; 12.5 h;
2: With ammonium acetate in acetonitrile
T=90°C; 0.5 h; microwave irradiation;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2005/82871 A2, 2005 ;
Location in patent: Page/Page column 109; 110 ;
WO 2005/082871 A2
反应条件
sodium hydroxide
T=90°C;
参考文献
Brands, Michael; Grande, Yolanda Cancho; Endermann, Rainer; Gahlmann, Reinhold; Krueger, Jochen; Raddatz, Siegfried
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2641 - 2645
反应条件
1: acetone / 0 °C
2: aq. NaOH / 90 °C
View Scheme
参考文献
Brands, Michael; Grande, Yolanda Cancho; Endermann, Rainer; Gahlmann, Reinhold; Krueger, Jochen; Raddatz, Siegfried
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2641 - 2645
