1-甲基-2-氧代-1,2-二氢-喹啉-4-羧酸合成路线 （共 13 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C; 16 h;
2: With hydrogenchloride in ethyl acetate
参考文献
GENENTECH, INC.
Patent: WO2006/69063 A1, 2006 ;
Location in patent: Page/Page column 96 ;
WO 2006/069063 A1
反应条件
ethanol; silver(l) oxide
参考文献
Cook; Stamper
Journal of the American Chemical Society, 1947 , vol. 69, p. 1467
反应条件
1: selenium dioxide / 175 °C
2: Ag2O; ethanol
View Scheme
参考文献
Cook; Stamper
Journal of the American Chemical Society, 1947 , vol. 69, p. 1467
反应条件
in methanol
0.666667 h; Irradiation;
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1: 35percent H2O2 / acetic acid / 7 h / 90 - 95 °C
2: 20.4 percent / methanol / 0.67 h / Irradiation
View Scheme
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1: 33percent aq. KOH / ethanol / Heating
2: 35percent H2O2 / acetic acid / 7 h / 90 - 95 °C
3: 20.4 percent / methanol / 0.67 h / Irradiation
View Scheme
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
参考文献
Thielepape
Chemische Berichte, 1922 , vol. 55, p. 133
Chemische Berichte, 1938 , vol. 71, p. 392
反应条件
1: diethyl ether
2: concentrated sulfuric acid / -15 °C
3: diluted NaOH-solution
View Scheme
参考文献
Thielepape
Chemische Berichte, 1922 , vol. 55, p. 133
Chemische Berichte, 1938 , vol. 71, p. 392
反应条件
1: concentrated sulfuric acid / -15 °C
2: diluted NaOH-solution
View Scheme
参考文献
Thielepape
Chemische Berichte, 1922 , vol. 55, p. 133
Chemische Berichte, 1938 , vol. 71, p. 392
反应条件
1: glacial acetic acid
2: glacial acetic acid
View Scheme
参考文献
Aeschlimann
Journal of the Chemical Society, 1926 , p. 2908
