4-[5-溴-3-[溴(2-氯苯基)甲基]-2-噻吩基]-3-(氯甲基)-5-甲基-4H-1,2,4-三唑合成路线 （共 2 条）
反应条件
1: NH3 / methanol 2: KMnO4 / acetone / Ambient temperature View Scheme
参考文献
Weber,K.-H. et al.
Justus Liebigs Annalen der Chemie, 1978 , p. 1257 - 1265
反应条件
1: 90 percent / KI, (i-Pr)2NEt, NH2OH*HCl / methanol / 2.5 h / Heating
2: 90 percent / HgO / acetone; CHCl3; H2O / 4 h / 20 - 25 °C
3: 57 percent / 2.5 h / 100 - 110 °C
4: 95 percent / imidazole / H2O; ethanol / 3 h / Heating
View Scheme
参考文献
Weber; Sirrenberg; Spohn; Daniel
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 3 A p. 518 - 521
