2-(2-氨基噻唑-5-基)乙酸乙酯合成路线 （共 7 条）
反应条件
in ethanol 3 h; Heating;
参考文献
Vitali; Impicciatore; Plazzi; Bordi; Morini
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 483 - 498
反应条件
1: hydrogen; 2,6-dimethylpyridine / palladium 10 on activated carbon / 24 h / 20 °C 2: bromine / 1,4-dioxane; diethyl ether / 1.5 h / 20 °C 3: ethanol / 8 h / Reflux View Scheme
参考文献
WO2010/144338 A1, ;
WO 2010/144338 A1
反应条件
1: 43 percent / Br2 / diethyl ether / 3.5 h / 0 °C 2: 70 percent / ethanol / 3 h / Heating View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 41, # 6 p. 483 - 498
反应条件
1: 50 percent / H2O; various solvent(s) / 2 h / 130 - 150 °C 2: 43 percent / Br2 / diethyl ether / 3.5 h / 0 °C 3: 70 percent / ethanol / 3 h / Heating View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 41, # 6 p. 483 - 498
反应条件
pyridine in dichloromethane; water; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4254260 A1, 1981 ;
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water
T=20°C;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
pH=3 - 4;
参考文献
ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; KORONIAK, Lukasz; DESAI, Neil
Patent: WO2010/144338 A1, 2010 ;
Location in patent: Page/Page column 119 ;
WO 2010/144338 A1
